EPPP Psychopharmacology Practice Exam 2025 – Comprehensive Test Preparation

Long-term use of lithium is notably associated with potential problems related to both thyroid function and kidney health. Lithium is primarily used in the treatment of bipolar disorder and can influence the function of the thyroid gland by causing hypothyroidism in some patients. This occurs because lithium can interfere with the synthesis and release of thyroid hormones.

Additionally, prolonged lithium therapy can affect kidney function, leading to conditions such as nephrogenic diabetes insipidus, where the kidneys are less able to concentrate urine, resulting in increased thirst and urination. Monitoring kidney function and thyroid levels is essential for patients on long-term lithium therapy, making awareness of these issues critical in managing treatment effectively.

These long-term effects underscore the importance of regular medical check-ups for individuals who are prescribed lithium to ensure that any potential issues are identified and addressed promptly.